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What is needed to facilitate the transition from the Inflammatory Phase to the Proliferative/Rebuilding Phase in wound healing?
High-risk diabetic patients
Stem cells
Growth factors
Anticoagulants
The correct answer is: Growth factors
The transition from the Inflammatory Phase to the Proliferative/Rebuilding Phase in wound healing is crucial for the progression of tissue repair. Growth factors play a significant role in this process. During the inflammatory phase, the body’s immune response is activated to clear debris and bacteria, which is essential for preventing infection. Once this phase is adequately addressed, growth factors are released to stimulate cellular processes that facilitate tissue granulation, angiogenesis (formation of new blood vessels), and the proliferation of fibroblasts and keratinocytes. These growth factors, such as Transforming Growth Factor (TGF), Vascular Endothelial Growth Factor (VEGF), and Platelet-Derived Growth Factor (PDGF), are naturally occurring proteins that signal cells to migrate, proliferate, and synthesize extracellular matrix components. Their presence is necessary to ensure that the wound can progress effectively to the next phase of healing, which focuses on rebuilding and tissue formation. In contrast, while stem cells can be involved in more advanced wound healing strategies, their role is generally more about regeneration and cellular replacement rather than facilitating the transition between these two key phases. Similarly, high-risk diabetic patients present challenges that can hinder healing rather than facilitate it, and anticoagulants are used to