Certified Wound Care Nurse (CWCN) 2025 – 400 Free Practice Questions to Pass the Exam

Neoangiogenesis refers specifically to the process of forming new blood vessels, which is critical in wound healing. This process typically occurs during the proliferative phase of healing, when oxygen and nutrients must be delivered to the site of injury to support tissue regeneration. Adequate blood supply is essential, as it not only brings the necessary components for tissue repair but also aids in the removal of waste products from the wound area.

The formation of new blood vessels is mediated by various growth factors and involves endothelial cells, which line the blood vessels, proliferating and migrating to form capillary loops. This vascularization is important for the development of granulation tissue, which forms part of the overall healing process, but the term neoangiogenesis specifically highlights the creation of new vascular structures.

While the repair of nerve endings, growth of tissue granulation, and formation of scar tissue are also significant aspects of wound healing, they do not define the process of neoangiogenesis itself. Each of these processes occurs in different phases of healing, with granulation tissue forming after neoangiogenesis has contributed to a sufficient blood supply. Thus, the term is appropriately associated with the critical role of angiogenesis in supporting the overall healing cascade.